Best Probiotics for SIBO and Histamine Intolerance

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Research shows various strains of probiotics for SIBO and histamine intolerance can help reduce bacteria in the small intestine, and histamine symptoms, but not all probiotic supplements are beneficial. Many people with SIBO also suffer from histamine intolerance, and following a low fodmap diet and low histamine diet is very restricting and does not resolve the root causes. 

Taking a probiotic when someone has SIBO may seem counterintuitive as there is an overgrowth of bacteria in the small intestine already. But dysbiosis is associated with a leaky gut and thus deficiency in the DAO enzyme that breaks down histamine in the gut. Plus, the overgrowth of pathogenic bacteria in the small intestine can cause histamine release. 

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Diamine oxidase is an enzyme primarily located in the intestinal lining. While a DAO deficiency can be due to genetic SNPs that reduce the ability to break down histamine, another root cause of DAO deficiency and histamine intolerance is an alteration in the microbiota.

Research shows a correlation between irritable bowel syndrome and intestinal inflammation that causes a decrease in DAO and lactase activities, resulting in histamine intolerance and lactose intolerance. 

While I don’t recommend many probiotics for SIBO, I have used L Rhamnosus and Probiota HistaminX with success when someone had symptoms of histamine intolerance, even when IBS and SIBO symptoms were present. Additional strains of probiotics have been proven beneficial for SIBO as well.

A meta-analysis of 18 studies concluded that probiotics were beneficial for SIBO and were associated with a decreased risk of developing SIBO and a significant reduction in abdominal pain associated with SIBO. Although probiotics cannot prevent SIBO, they help reduce SIBO symptoms, such as abdominal pain, a sign of histamine intolerance. 

Taking probiotics that help reduce bacterial overgrowth, improve the integrity of the gut lining, and degrade histamine can help people suffering from SIBO and histamine intolerance. 

Plus, many SIBO symptoms and histamine intolerance symptoms overlap, such as:

• bloating
• abdominal pain
• diarrhea
• heartburn
• nausea

Probiota HistaminX is the best probiotic brands for histamine intolerance, especially if you suffer from histamine symptoms such as:

• allergies
• nasal congestion
• itchy skin
• headaches
• chest pain

Using a low histamine probiotic with histamine reducing bacteria such as Probiota HistaminX can help to reduce histamine in the body. It shouldn’t come as a surprise that histamine intolerance is connected to the gut microbiome. 

Some gut bacteria produce a lot of histamine, while other probiotic bacteria strains break histamine down. A healthy gut plays a role in maintaining normal histamine metabolism and healthy histamine levels.

If the gut contains many histamine producing bacteria, an individual may become sensitive to high-histamine foods. Rebalancing the gut with histamine degrading bacteria is crucial for reducing the frustrating symptoms of histamine intolerance.

When it comes to histamine in the body, it is all about balance. Histamine is not all bad news. In fact, histamine is needed by the immune system to:

• fight pathogens
• stimulate stomach acid production
• and stimulate motility in the small intestine.

Excess histamine in the gut will leave you feeling frustrated and not knowing what is causing your symptoms. Is it your gut? Is it the food you ate? Or is it stress?

The answer is yes to all those questions.

The benefit of histamine reducing bacteria 

A healthy gut balanced with histamine-friendly probiotics and specific probiotic strains that reduce histamine can help build up your histamine tolerance level.

When the gut is balanced with histamine degrading bacteria instead of histamine producing bacteria, you will be able to tolerate high-histamine foods much better. You should at least be able to reduce your symptoms of histamine intolerance.

Excess histamine produced by your microbiome gets absorbed into your body, leading to a wide variety of histamine symptoms. The symptoms of histamine intolerance can be so diverse, yet the root cause is excess histamine coming from the gut.

The key to reducing the excess histamine from being absorbed is to lower the histamine in the gut by providing your microbiome with histamine degrading probiotics that do not produce histamine and instead help to break down histamine.

Bacteria that produce histamine include:

• Candida
• Citrobacter Freundii
• H.pylori
• E.coli
• Morganella Morganii
• Lactobacillus bulgaris
• Lactobacillus casei
• Staphylococcus
• Klebsiella spp

Histamine reducing probiotics include:

• Bifidobacterium infantis
• Bifidobacterium longum
• Bifidobacterium Breve
• Lactobacillus Plantarum

Why Probiota HistaminX is the best probiotic for histamine intolerance

Probiota HistaminX by Seeking Health is an amazing probiotic for histamine intolerance. This probiotic helps to rebalance the microbiome with good bacteria that can reduce histamine in the gut. It contains histamine degrading bacteria such as Bifidobacterium infantis and Bifidobacterium longum.

These potent probiotic strains for histamine-sensitive individuals help to support a healthy histamine response by reducing excess histamine coming from the gut.

Probiota HistaminX is the best probiotic brand for histamine intolerance that I have come across. This low histamine probiotic is my number 1 probiotic supplement for histamine intolerance.

I use Probiota HistaminX for my clients when I suspect histamine intolerance due to an unbalanced microbiome with too many histamine producing bacteria in the gut. Balancing the gut with histamine reducing bacteria is essential for reducing symptoms of histamine intolerance.

Probiota HistaminX helps to rebalance the microbiome with probiotic strains shown to help degrade histamine in the gut!

Probiota HistaminX is a low histamine probiotic that excludes probiotic strains known to produce histamine. An easy way to use this probiotic is by putting it in this low histamine mango smoothie.

L Rhamnosus for SIBO and histamine Intolerance

L Rhamnosus is another one of the top probiotics for SIBO and histamine intolerance as it has been shown to reduce the expression of genes and receptors involved in mast cell activation syndrome. L rhamnosus and the combination of 4 other probiotics had the most profound effect on lowering mast cell activation that is associated with allergic reactions and histamine intolerance by downregulating the histamine receptor genes.

This probiotic also upregulated anti-inflammatory functions to reduce inflammation. Without a doubt, L rhamnosus is one of the best probiotics for SIBO and histamine intolerance. 

Soil-based probiotics for SIBO and histamine intolerance

• Bacillus clausii
• Bacillus coagulans 
• Bacillus subtilis 

Bacillus clausii, bacillus coagulans, and bacillus subtilis are soil based probiotics that are beneficial for both SIBO and histamine intolerance. The primal earth probiotic contains these three strains of bacteria and was formulated to combat SIBO. It is unique to other probiotics as these probiotics don’t populate the small intestine.

Instead, they travel through the stomach and small intestine intact and colonize the large intestine, where they support optimal gut health. This is highly beneficial for people with SIBO as you don’t want to populate the small intestine with probiotic bacteria that will take up residence in the small intestine and fuel the existing overgrowth.

The primal earth probiotic is also beneficial for people with histamine issues as bacillus subtilis breaks down biogenic amines such as histamine and tyramine found in histamine-rich foods. Bacillus clausi has immune-modulating effects that reduce inflammation and allergic symptoms.

Repopulating the microbiome with the specific types of bacteria found in HistaminX, Primal Earth, and L Rhamnosus are the best probiotics for SIBO and Histamine intolerance as the combination of strains helps to combat bad bacteria, modulate the immune system and thus reduce the release of histamine.

Taking high-quality probiotics such as these can help histamine intolerant people with IBS eat high-histamine foods again or at least help break down excess histamine in the gut.