Probiota Histaminx, liposomal vitamin c, and histamine block are the best supplements to reduce histamine. But how are these supplements so effective at reducing histamine in the body and the symptoms associated with histamine intolerance?
Best probiotic for SIBO and histamine intolerance
While most probiotic supplements contain strains of bacteria that reduce histamine and produce histamine to allow for a diverse probiotic supplement, it does not help the individual who has symptoms of histamine intolerance and is looking for the best probiotic supplement for histamine intolerance.
The best probiotic strains for histamine intolerance are Bifidobacterium infantis, Bifidobacterium longum, lactobacillus brevis, and Lactobacillus plantarum, which are in Probiota HistaminX.
Some common probiotics that produce histamine in the gut include lactobacillus casei and lactobacillus bulgaricus. None of these strains of probiotics are in Probiota HistaminX. While these probiotics still have beneficial properties, they may not be best for the histamine-sensitive individual.
Some other bacteria that have been shown to produce histamine in large amounts include oxytoca, Citrobacter freundii, and Enterobacter cloacae. These bacteria are often in higher levels in people with gut dysbiosis and SIBO. People with SIBO often have histamine intolerance due to too much histamine-producing bacteria in the small intestine.
Utilizing a probiotic with bacteria that reduces histamine in the gut helps balance the microbiome and ensures that DAO enzyme and HNMT enzyme are not overloaded with histamine to break down from the small and large intestine. Probiota is one of the best probiotics for SIBO and histamine intolerance, and I have seen great results with several clients and customers using this probiotic.
I am often wary of using probiotics, especially when I suspect SIBO may be present. Still, Probiota HistaminX is well tolerated in individuals with SIBO and is one of the best probiotic brands for histamine intolerance, with probiotic strains to reduce histamine in the body.
The best supplement to reduce histamine that comes from food
Dao Enzyme by Seeking Health contains the enzyme diamine oxidase, which helps metabolize food sources of histamine and histamine coming from the gut and outside the cell.
The DAO enzyme is primarily located in large amounts in the intestinal lining. If the gut lining is damaged due to a leaky gut or even excess histamine caused by bacteria or mast cell activation, the DAO loses enzymes. A loss of the DAO enzyme decreases the ability to metabolize and reduce histamine in the body, thus contributing to histamine symptoms.
Some individuals may have SNP’s in the DAO enzyme; therefore, they genetically have a decreased ability to metabolize external histamine from foods and bacteria in the gut and thus easily get overwhelmed in general or when eating high histamine foods.
Supplementing with diamine oxidase helps to metabolize external histamine from food sources and in the gut.
Take DAO Enzyme with high histamine foods to help break down histamine from food. This supplement is beneficial for someone who does not tolerate high histamine foods, has a leaky gut, SNP’s in the DAO gene, or a full histamine bucket.
Vitamin C for histamine intolerance
Vitamin C is another fantastic supplement to reduce histamine and stabilize the mast cell.
Mast cells are immune cells that, when stimulated, release pro-inflammatory compounds such as histamine as one of the inflammatory compounds released. When mast cells are activated, reactive oxygen species are produced, and vitamin C is an antioxidant that protects the immune cells from reactive oxygen species.
Vitamin c is one of the best vitamins for immune support and has been shown to decrease bronchial hypersensitivity and helps to reduce the duration of the common cold, sneezing, coughing, runny nose, and other symptoms related to mast cell activation and the release of histamine.
Seeking health’s liposomal vitamin c plus is a great vitamin c for histamine intolerance for several reasons. First, a liposomal vitamin c makes this vitamin c readily absorbed and utilized by the body as phosphatidylcholine acts as a delivery mechanism to get vitamins inside the cell.
This vitamin c also contains lutein and quercetin, which help stabilize mast cells that produce histamine to help with allergy-like symptoms of histamine intolerance and is mixed with bioflavonoids required for optimal utilization of vitamin c in the body.
The phosphatidylcholine found in this liposomal vitamin c also indirectly supports the HNMT enzyme, which is responsible for breaking down histamine found inside the cell instead of outside the cell. The HNMT enzyme requires a methyl donor called SAMe as a cofactor for this gene to function. 70-80 percent of SAMe is used to make phosphatidylcholine.
By providing the body with phosphatidylcholine in this liposomal vitamin c, SAMe can work elsewhere in the body and more SAMe is available for the HNMT enzyme to work and reduce histamine.
The combination of Probiota HistaminX, Liposomal Vitamin C, and DAO Enzyme are the best supplements to reduce histamine in the body.
This low histamine mango smoothie is great for anyone suffering from histamine intolerance.
Related Articles:
Histamine Intolerance : How to Reduce Histamine in The Body
Poor Methylataion, MTHFR and Histamine Intolerance
Grab your FREE step by step gut health guide here
References:
https://www.jstage.jst.go.jp/article/jphs/107/2/107_08028FP/_article
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136002/
https://www.longdom.org/open-access/relationship-between-vitamin-c-mast-cells-and-inflammation-2155-9600-1000456.pdf
Hi Amber,
I have truly enjoyed reading the articles on your website as there is not a lot of information out there on histamine intolerance.
For the last couple years I have found myself waking up or going to bed with random hives and patches of bumpy, dry skin that looks like eczema. Splotches of red skin whenever I drink wine. I’ve tried every cream, even steroids with no success. The hives are on my thighs, my torso, even my back and sometimes on my forearms.
I recently took a food intolerance test and had a lot of above average or “abnormal” reactions to things. Some of them I don’t even eat (scallops, cottage cheese) the more research I did, the more I found on histamine intolerance. When I read some of the foods that contain histamine or release histamine I cross checked it with my test results. It turns out many things I had a reaction to, has or releases histamine (Banana, cheese, coffee, eggs, eggplant, milk, peanuts, bakers and brewers yeast, yogurt) I also had intolerance to gluten, barley, bran, corn, rye, black pepper and blueberries.
It’s not doctor confirmed, but it sounds to me like I have histamine intolerance, & issues with DAO, so I am going to try they supplements you suggested to see if they help, and Im going to do my best to cut out histamine foods.
I had a couple of questions and would love your insight on them if you can give it.
I drink coffee everyday, not a lot, but at least 1 cup with almond milk, no sugar. Is there a good alternative? I read tea (like matcha annd green tea) are DAO blockers, which would be bad in my case. It’s worth noting that on this food intolerance test they did not test for green tea but they did test for black tea and I had no reaction, but I had an abnormal reaction to coffee. Perhaps tea if a better caffeine choice for me?
I also wanted to ask about olives and tomatoes. I know tomatoes are on the list of foods to avoid, but I’ve also read if they are cooked then they are ok? like sauteed, or even in a pasta sauce? Is there any truth to that? And I’ve read to avoid olives, but what if they come in a can of water and sea salt, and not vinegar?
I appreciate any feedback!!
Hi Breana! Thanks for your questions and sharing your story. Yes histamine intolerance can be a bit of a pain but identifying the most troublesome foods is a huge step which you have already done!
I don’t know if matcha and green tea inhibit the DAO enzyme as I havn’t read or researched that and same for the olives. Everyone is unique in their ability to metabolize different substances found in food but I would focus on limiting and avoiding the histamine foods that you really notice are problematic along with your food sensitivities. A lot could be going on in the gut as well but I would think olives without the vinegar would be fine. I like to always go by your bodies response as well where you can avoid all the histamine foods then challenge some of the lower histamine foods one at a time to see if you are reacting to them.
Genetic testing can also be helpful to see if you are prone to having trouble metabolizing histamine through various genes such as the DAO, HNMT, MAO A and NAT2 genes to see if and where you are genetically likely to be struggling.
I personally was clear in the DAO gene but had a snp in the MAO A gene which metabolizes histamine as well. Olives can contain different levels of biogenic amines which is metabolized through the MAO A gene. Aged Cheeses contain tyramine and are metabolized through this gene as well. I notice that I get puffy and dont do well with too much cheese olives or smoked meats…. so everyone is a bit different
Here is a link to a study on olives and the biogenic amines found in it.
https://www.ncbi.nlm.nih.gov/pubmed/10643779
I have a hard time giving up coffee as well!! I have substituted dandelion root tea for coffee instead and enjoyed it and I have also mixed it half and half with my coffee so that I am only drinking half a cup of coffee.
Hope that helps :)
Hi Breana! Thanks for your questions and sharing your story. Yes histamine intolerance can be a bit of a pain but identifying the most troublesome foods is a huge step which you have already done!
I don’t know if matcha and green tea inhibit the DAO enzyme as I havn’t read or researched that and same for the olives. Everyone is unique in their ability to metabolize different substances found in food but I would focus on limiting and avoiding the histamine foods that you really notice are problematic along with your food sensitivities. A lot could be going on in the gut as well but I would think olives without the vinegar would be fine. I like to always go by your bodies response as well where you can avoid all the histamine foods then challenge some of the lower histamine foods one at a time to see if you are reacting to them.
Genetic testing can also be helpful to see if you are prone to having trouble metabolizing histamine through various genes such as the DAO, HNMT, MAO A and NAT2 genes to see if and where you are genetically likely to be struggling.
I personally was clear in the DAO gene but had a snp in the MAO A gene which metabolizes histamine as well. Olives can contain different levels of biogenic amines which is metabolized through the MAO A gene. Aged Cheeses contain tyramine and are metabolized through this gene as well. I notice that I get puffy and dont do well with too much cheese olives or smoked meats…. so everyone is a bit different
Here is a link to a study on olives and the biogenic amines found in it.
https://www.ncbi.nlm.nih.gov/pubmed/10643779
I have a hard time giving up coffee as well!! I have substituted dandelion root tea for coffee instead and enjoyed it and I have also mixed it half and half with my coffee so that I am only drinking half a cup of coffee.
Hope that helps :)
Hi Amber,
I am struggling with histamine intolerance. Been trying to be my own health advocate. What testing and where can I purchase for food sensitivity or what you recommend?
Hi Marisa,
I use genetic testing to determine if someone is prone to poor metabolism of histamine and which pathway it is coming from. But I also just remove high histamine trigger foods while working on gut health and SIBO and that helps with histamine intolerance as well.
If you need one on one support let me know. I am happy to provide a complimentary 15 minute phone call to answer any questions.
I know histamine intolerance can be a struggle.
Do you recommend a probiotic for people with dairy allergies? My son tests low but positive for dairy allergies (cow’s milk protein). His only reaction is sneezing and runny nose, but it’s constant. His allergist thought he’d outgrow it because it was so low and so we thought leaky gut was the real issue. He is slowly becoming intolerant of everything and I’m running out of ideas. I don’t know where to start and feel overwhelmed. He’s taking lactase, a papaya enzyme, and betaine with lipase each meal. He started all that this week. We are new to trying this approach. He is nearly 20 years old and takes nothing else (no medications) if that helps. I appreciate advice I can get at this point. Thank you so much.
Hmm, not exactly sure but sneezing and a runny nose are also histamine symptoms and probiota histaminx by seeking health is amazing for helping to reduce histamine symptoms as it contains bacteria that help to metabolize histamine in the gut. Without knowing more thats the first thing that comes to mind as a possibility.
With great respect and kindness, I am taking a moment to say that all of this symptom chasing and gene evaluation and deep dive into diets and supplements can be for some a symptom of a trauma/stress loop. I have healed everything you’re talking about (I have MTHFR and did the whole strategene and supps and diet and SIBO protocols and FMT and EVERYTHING for 10 years) through neural retraining (DNRS). I think there are a huge percentage of people pursuing all of this who are in the same loop. When Pinterest shares blogs like this with me, I scan through them, and feel amazing relief that I don’t have to do this anymore! I’m free.
I agree, trying to solve our health challenges can be stressful and overwhelming. I am so glad you have healed everything and feel free. That is the ultimate goal :)
I have a DAO mutation. Also have IBD. My Dr. that ran my DNA put me on Histamine block. From seeking health I’m wondering if the nutrient one would also be good for me with mine being genetic are there any concerns with that supplement?
Hi Becky, Are you noticing improvements with that supplement? Every one can respond differently to supplements so even tho I dont have any concerns with that supplement always check with your doctor and take note of how you feel. I have also seen success with probiota histaminx which contains bacteria that break down histamine in the gut so that your DAO enzyme isnt as overwhelmed by histamine.